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Peroxynitrite reacts NAD NADH O2 Acetyl CoA Arginine O2 ADP ATP O2 H2O2 Citrulline NO O2 Lipases O2,LOOL Epoxygenase Lipoxygenase Cyclooxygenase Sources of Oxygen Radicals Arachidonic acid oxidation Mitochondrial electron transport CO2 Lipoxins Hepoxilins Leukotrienes Prostanoids HETES Xanthine oxidase NADPH oxidase Monoamine oxidase Glucose oxidase P450 enzymes Ca2 CaM Nitric oxide synthase FMN H4T FAD Fe2 FIGURE 32-7 Sources of free radical formation which may contribute to injury during ischemiareperfusion.
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